19/10/2022
Safety of inositol supplementation in patients taking lithium or valproic acid: a pilot clinical study
Autori: T. Cantelmi, E. Lepore, Vr. Unfer, V. Unfer
Articolo pubblicato sulla rivista European Review for Medical and Pharmacological Sciences (IF 3.784). Abstract.OBJECTIVE: Mood stabilizers like lithium (Li) and valproic acid (VPA) act via cellular depletion of inositol in the central nervous system (CNS). However, such depletion also involves peripheral tissues, thus exposing patients to various side effects. Preclinical and clinical studies revealed the effectiveness of inositol supplementation to recover such pathological conditions. Nevertheless, the risk of reducing the effectiveness of pharmacological therapies by raising inositol levels in the CNS, still represents a matter of concern. This study adds new insights on this aspect, highlighting the safety of a tailored dosage of inositol in patients taking Li or VPA...




